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AKA-377
AkProva™ Metildigoxin
Cat. No.
AKA-377
CAS No.
30685-43-9(acetone-free)
MF
C42H66O14.1/2C3H6O
MW
824
AkProva™ Metildigoxin is a substrate of the ATP-dependent efflux pump P-glycoprotein. Metildigoxin's polarized transport could be completely inhibited by 1μM PSC-833
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Technical Data
Description
Storage and Shipping
References
Product Name
AkProva™ Metildigoxin
CAS No.
30685-43-9(acetone-free)
MF
C42H66O14.1/2C3H6O
MW
824
Specification
JP18
Description
AkProva™ Metildigoxin is a substrate of the ATP-dependent efflux pump P-glycoprotein. Metildigoxin's polarized transport could be completely inhibited by 1μM PSC-833 Packing: 10g/bag，50g/bag,100g/bag API Current Development Status: A3---Process Development / Scale-Up Reference: Aktin major API development processes: A1.Feasibility / Route Development A2.Laboratory Process Development A3.Process Development / Scale-Up A4.GMP Clinical Development A5.Commercial GMP Supply
Documents
Certificate of Analysis (COA), API specification, Safety Data Sheet (SDS/MSDS), evidence of GMP compliance, Stability data / Stability summary, etc.
Storage and Shipping
Store in a cool and dry place, avoid strong light and high temperature
References
[1].Funakoshi S, Murakami T, Yumoto R, Kiribayashi Y, Takano M. Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and β-methyldigoxin in rats. J Pharm Sci. 2003;92(7):1455-1463. doi:10.1002/jps.10416.
[2].C Pauli-Magnus, et al. P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43.
[3].Franzmaier R, inventor; Chemie Linz Aktiengesellschaft, assignee. Process for the preparation of β-methyldigoxin. US patent 4,603,196. July 29, 1986.
[2].C Pauli-Magnus, et al. P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43.
[3].Franzmaier R, inventor; Chemie Linz Aktiengesellschaft, assignee. Process for the preparation of β-methyldigoxin. US patent 4,603,196. July 29, 1986.
Disclaimer
The information provided on generic APIs is for general reference and market assessment purposes only. Regulatory status, market availability, specifications, patents, and commercial terms may vary by country and change over time. Users should independently verify all information with the relevant regulatory authorities and qualified professionals before making any regulatory, manufacturing, investment, or commercial decisions. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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